Suspicion of sepsis : Improving the Signal to Noise Ratio The concept of the SoS paper is reasonable (Inada-Kim M, Page B, Maqsood I, et al Defining and measuring suspicion of sepsis: an analysis of routine data BMJ Open 2017;7:e014885. doi: 10.1136/bmjopen-2016-014885) . We know that coding of sepsis is poor. This absence of reliable data makes it hard to compare approaches over time and between locations. The SoS paper basically lists a lot of codes that the authors associated with infection. The authors identified 267 codes indicating possible infection. There were 47475 cases with these codes as a primary diagnosis, with 3440 associated deaths. We felt that several of these reflected conditions that were not primarily infective in nature (or at least in which antibiotics would not be a main component of acute management) We removed the most common of these. 11. N12.X - Tubulo-interstitial nephritis, not specified as acute or chronic 13.